SPOILER ALERT! WEEKEND writers take on the task of summing up some of 2007's biggest shows

SEASON 4 PREMIERE: 9 p.m. Thursday, Sept. 27, on ABC\nSUMMARY: Last season sent fans into panic, wondering where Creator Shonda Rhimes would take the show next. It ended with Meredith (Ellen Pompeo) and Derek (Patrick Dempsey) reaching an emotional turning point in their relationship. Christina (Sandra Oh) and Preston (Issiah Washington) failed to get married. George (T.R. Knight) failed his exam and will be back to repeat an internship in season four. Callie (Sara Ramirez), whose husband George (T.R. Knight) cheated on her with Izzie (Katherine Heigl), was named chief resident. Viewers received a glimpse of some new interns, one being Meredith's half-sister Lexie (Chyler Leigh).\nPREDICTION: It's hard to predict what will happen, since season three left so many questions in the air. Lexie will likely interfere with Meredith and Derek's relationship. George won't get off easily for having slept with Izzie, and Callie will likely find out about the affair, and he will have to make a decision. As Callie enters the season as chief resident, Dr. Bailey (Chandra Wilson) who vied for the position, will question where she belongs at the hospital. As for Christina, it's hard to say what she will do since Preston is now gone, but she may have a hard time getting over him.