Against Michigan, the senior forward tied and passed Jill Chapman’s career mark of 197 blocks.
The Minnesota transfer set a new high for points scored since joining the team.
The sold-out crowd will likely set an attendance record for the Hoosiers.
The Hoosiers went 0-3 against the Hawkeyes last season, including a loss in the Big Ten Championship.
Moore-McNeil was the most productive Hoosier in a contested first half.
With the win, the Hoosiers complete the weekend sweep of the rival Boilermakers.