Indiana stranded the bases loaded in the eighth inning before losing the lead in a 9-8 loss on Sunday.
The Hoosiers were losing by two runs heading into the bottom of the eighth inning.
Indiana evened the three-game series on Saturday and won Sunday’s finale to take the series.
The Hoosiers are 20-24 this season after a 2-1 weekend against the Illini.
Carter Mathison and Josh Pyne have been some of the biggest contributors in recent games.
Indiana beat Illinois in the series opener 7-6 on Friday afternoon.
Indiana will play three games against Illinois for its second home series in a row.
Pitcher Luke Hayden improved to 4-0 while Reese Sharp earned his second consecutive save.
Pyne earned Big Ten honors after a strong performance against Nebraska last weekend.
Braydon Tucker and Ty Bothwell allowed five hits combined in downtown Indianapolis.
Carter Mathison scored Indiana’s eighth run in a narrow 8-7 series-opening victory.
The Hoosiers won two of three games against the Cornhuskers over the weekend.
Indiana lost to Miami University 9-7 on Tuesday night after leading 3-0.
Indiana will face Miami University (Ohio) on Tuesday and the University of Cincinnati on Wednesday.
The Hoosiers led each game heading into the bottom of the eighth inning over the weekend.